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	51. 2209 Accesses	Minireview Regulation of metabolism in Caenorhabditis elegans longevity Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.
	52. 2207 Accesses	Research article A global analysis of genetic interactions in Caenorhabditis elegans Alexandra B Byrne, Matthew T Weirauch, Victoria Wong, Martina Koeva, Scott J Dixon, Joshua M Stuart, Peter J Roy Journal of Biology 2007, 6:8 (26 September 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A C. elegans genetic-interaction network built by combining gene mutants and knockdowns is the largest animal network to date, revealing redundancy among functional modules and surprisingly little conservation of network connections compared to yeast.
	53. 2197 Accesses	Research article Astrocytes derived from glial-restricted precursors promote spinal cord repair Jeannette E Davies, Carol Huang, Christoph Proschel, Mark Noble, Margot Mayer-Proschel, Stephen JA Davies Journal of Biology 2006, 5:7 (27 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Significantly better spinal cord repair in rats results from transplanting specific pre-differentiated cells, cultured to become immature neural-support cells, than from transplanting undifferentiated embryonic stem cells.
	54. 2126 Accesses	Minireview How chemotherapy damages the central nervous system Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	55. 2084 Accesses	Research article A circuit supporting concentration-invariant odor perception in Drosophila Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall Journal of Biology 2009, 8:9 (26 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila, inhibitory interneurons are progressively recruited as olfactory sensory neurons are activated at increasing odor concentrations, allowing the flies to identify distinct odors at different intensities.
	56. 2075 Accesses	Research article The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.
	57. 2078 Accesses	Minireview Metabolic reconfiguration is a regulated response to oxidative stress Chris M Grant Journal of Biology 2008, 7:1 (25 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	58. 2041 Accesses	Research article Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone, Frederick P Roth Journal of Biology 2005, 4:6 (1 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The multiple complex biological interactions in a yeast cell can be mapped in a simple graphical form, enhancing our understanding of the networks of interaction by which components of a cell influence one another.
	59. 2031 Accesses	Opinion Promoter architecture and the evolvability of gene expression Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.
	60. 2007 Accesses	Opinion The 'stem cell' concept: is it holding us back? Arthur D Lander Journal of Biology 2009, 8:70 (21 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary Arthur Lander argues that the molecular definition of a stem cell is a mirage and 'stemness' is an emergent property of cells in their physiological context, so that the current concept is arguably an obstacle to research.
	61. 1975 Accesses	Minireview The cattle genome reveals its secrets David W Burt Journal of Biology 2009, 8:36 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.
	62. 1971 Accesses	Research article Evidence for large domains of similarly expressed genes in the Drosophila genome Paul T Spellman, Gerald M Rubin Journal of Biology 2002, 1:5 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	63. 1968 Accesses	Research article Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.
	64. 1955 Accesses	Research article Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression Ian Conlon, Martin Raff Journal of Biology 2003, 2:7 (24 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| F1000 Biology
	65. 1949 Accesses	Minireview Regeneration review reprise Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.
	66. 1940 Accesses	Research article Global analysis of X-chromosome dosage compensation Vaijayanti Gupta, Michael Parisi, David Sturgill, Rachel Nuttall, Michael Doctolero, Olga K Dudko, James D Malley, P Scott Eastman, Brian Oliver Journal of Biology 2006, 5:3 (16 February 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila germ cells, X chromosome genes are upregulated to balance their expression with that of autosomes; the same happens in somatic cells of mice and nematodes.
	67. 1939 Accesses	Question & Answer Q&A: What are pharmacological chaperones and why are they interesting? Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009) Full text \| PDF \| PubMed \| Editor’s summary Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
	68. 1918 Accesses	Research article Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury Jeannette E Davies, Christoph Pröschel, Ningzhe Zhang, Mark Noble, Margot Mayer-Pröschel, Stephen JA Davies Journal of Biology 2008, 7:24 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Glial cells can promote the repair of damaged spinal cord, but experiments in rats show that while some promote functional recovery others cause abnormal growth and pain, depending on the growth factor used to cultivate them in culture.
	69. 1899 Accesses	Minireview The genetics of gender and life span John Tower, Michelle Arbeitman Journal of Biology 2009, 8:38 (29 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Tower and Arbeitman discuss two studies in BMC Evolutionary Biology showing that the genetic differences between male and female seed beetles and in fruit flies have a significant effect upon aging and life span.
	70. 1891 Accesses	Review Notch signaling, the segmentation clock, and the patterning of vertebrate somites Julian Lewis, Anja Hanisch, Maxine Holder Journal of Biology 2009, 8:44 (22 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Julian Lewis and colleagues review the part played by the Notch signaling pathway in the emergence of somites from the embryonic mesoderm and their later differentiation.
	71. 1885 Accesses	Research article Environmental stresses can alleviate the average deleterious effect of mutations Roy Kishony, Stanislas Leibler Journal of Biology 2003, 2:14 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology
	72. 1859 Accesses	Minireview Islands in the sky: the impact of Pleistocene climate cycles on biodiversity Allan J Baker Journal of Biology 2008, 7:32 (3 November 2008) Abstract \| Full text \| PDF \| PubMed
	73. 1831 Accesses	Minireview Apical polarity in three-dimensional culture systems: where to now? Jamie L Inman, Mina J Bissell Journal of Biology 2010, 9:2 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	74. 1791 Accesses	Question & Answer Q&A: Cooperativity James E Ferrell Journal of Biology 2009, 8:53 (16 June 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary James Ferrell explains in Q&A format how cooperativity can tune the behaviour of biological macromolecules to their physiological functions, and can be achieved in many different ways.
	75. 1786 Accesses	Minireview RNA interference in nematodes and the chance that favored Sydney Brenner Marie-Anne Félix Journal of Biology 2008, 7:34 (13 November 2008) Abstract \| Full text \| PDF \| PubMed