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	1. 539 Accesses	Minireview Small changes, big results: evolution of morphological discontinuity in mammals Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008) Abstract \| Full text \| PDF \| PubMed
	2. 520 Accesses	Comment Are we training pit bulls to review our manuscripts? Virginia Walbot Journal of Biology 2009, 8:24 (9 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| Editor’s summary Virginia Walbot accepts some of the blame for remorselessly negative reviewers, and suggests a training program for graduate students and post docs that will deliver a fairer assessment of manuscripts.
	3. 405 Accesses	Research article Growth control of the eukaryote cell: a systems biology study in yeast Juan I Castrillo, Leo A Zeef, David C Hoyle, Nianshu Zhang, Andrew Hayes, David CJ Gardner, Michael J Cornell, June Petty, Luke Hakes, Leanne Wardleworth, Bharat Rash, Marie Brown, Warwick B Dunn, David Broadhurst, Kerry O'Donoghue, Svenja S Hester, Tom PJ Dunkley, Sarah R Hart, Neil Swainston, Peter Li, Simon J Gaskell, Norman W Paton, Kathryn S Lilley, Douglas B Kell, Stephen G Oliver Journal of Biology 2007, 6:4 (30 April 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The first comprehensive systems biology study on growth rate control in yeast integrates information from the transcriptome, proteome and metabolome to reveal how cell growth underlies key cellular and development processes.
	4. 402 Accesses	Opinion Top dogs: wolf domestication and wealth Carlos A Driscoll, David W Macdonald Journal of Biology 2010, 9:10 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on a phylogeographic analysis in BMC Biology that supports a Middle Eastern origin of small dogs, Driscoll and Macdonald speculate on the implications of wolf domestication and size reduction occurring at a time of transition between hunter-gatherer and sedentary societies.
	5. 374 Accesses	Minireview Music, memory and emotion Lutz Jäncke Journal of Biology 2008, 7:21 (8 August 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	6. 344 Accesses	Comment Open access to the scientific journal literature Peter Suber Journal of Biology 2002, 1:3 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	7. 344 Accesses	Research article Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach, Sylvia Krobitsch Journal of Biology 2007, 6:10 (21 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Yeast and C. elegans share a conserved cellular mechanism that counteracts the fatal consequences of oxidative stress by enabling the redirection of metabolic flux from glycolysis to the pentose phosphate pathway.
	8. 332 Accesses	Research article Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae Teresa Reguly, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Gary C Hon, Chad L Myers, Ainslie Parsons, Helena Friesen, Rose Oughtred, Amy Tong, Chris Stark, Yuen Ho, David Botstein, Brenda Andrews, Charles Boone, Olga G Troyanskya, Trey Ideker, Kara Dolinski, Nizar N Batada, Mike Tyers Journal of Biology 2006, 5:11 (8 June 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new literature-based yeast database documents over 33,000 biological interactions, manually curated from the primary literature, and provides an invaluable resource to benchmark high-throughput methods in the study of complex networks.
	9. 329 Accesses	Minireview Acoel and platyhelminth models for stem-cell research Alexandra E Bely, James M Sikes Journal of Biology 2010, 9:14 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The bodies of platyhelminth and acoel worms are continually renewed from large pools of somatic stem cells. Bely and Sikes discuss their consequent attractiveness for stem cell research, and how recent studies, including one in BMC Developmental Biology, reveal aspects of the cellular dynamics and molecular basis of stem-cell function in these animals.
	10. 313 Accesses	Research article Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila Silvia Gluderer, Erich Brunner, Markus Germann, Virginija Jovaisaite, Changqing Li, Cyrill A Rentsch, Ernst Hafen, Hugo Stocker Journal of Biology 2010, 9:9 (11 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stocker and colleagues identify and analyze a growth-promoting complex in Drosophila, formed between the putative transcription factor BunA, for which human homologs can functionally substitute, and the adaptor protein Madm.
	11. 308 Accesses	Research article A global analysis of genetic interactions in Caenorhabditis elegans Alexandra B Byrne, Matthew T Weirauch, Victoria Wong, Martina Koeva, Scott J Dixon, Joshua M Stuart, Peter J Roy Journal of Biology 2007, 6:8 (26 September 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A C. elegans genetic-interaction network built by combining gene mutants and knockdowns is the largest animal network to date, revealing redundancy among functional modules and surprisingly little conservation of network connections compared to yeast.
	12. 302 Accesses	Research article Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2008, 7:12 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary The chemotherapy drug, 5-fluorouracil, causes delayed degeneration in the central nervous system of animals, a newly identified type of damage that helps explain the cognitive defects or `chemobrain` symptoms associated with cancer treatment.
	13. 284 Accesses	Research article The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling Martin A Jünger, Felix Rintelen, Hugo Stocker, Jonathan D Wasserman, Mátyás Végh, Thomas Radimerski, Michael E Greenberg, Ernst Hafen Journal of Biology 2003, 2:20 (7 August 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	14. 277 Accesses	Minireview The origin and evolution of lactation Anthony V Capuco, R Michael Akers Journal of Biology 2009, 8:37 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Capuco and Akers review the biology of lactation and discuss a new report in Genome Biology that compares the bovine genome with six other mammalian genomes to study how lactation and its regulation evolved.
	15. 274 Accesses	Research article Conservation of core gene expression in vertebrate tissues Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.
	16. 273 Accesses	Research article Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade Simon A Hawley, Jérôme Boudeau, Jennifer L Reid, Kirsty J Mustard, Lina Udd, Tomi P Mäkelä, Dario R Alessi, D Grahame Hardie Journal of Biology 2003, 2:28 (24 September 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	17. 268 Accesses	Minireview SnoPatrol: how many snoRNA genes are there? Paul P Gardner, Alex Bateman, Anthony M Poole Journal of Biology 2010, 9:4 (25 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gardner, Bateman and Poole review the current knowledge of small nucleolar RNAs (snoRNAs) and discuss two BMC Genomic papers reporting the identification of novel snoRNAs and the likelihood that there are many more out there.
	18. 266 Accesses	Minireview The mathematics of sexual attraction José A Feijó Journal of Biology 2010, 9:18 (29 March 2010) Abstract \| Full text \| PDF \| PubMed
	19. 263 Accesses	Research article Bridge helix and trigger loop perturbations generate superactive RNA polymerases Lin Tan, Simone Wiesler, Dominika Trzaska, Hannah C Carney, Robert OJ Weinzierl Journal of Biology 2008, 7:40 (2 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mutations targeted to key functional areas of RNA polymerases can generate superactive enzymes that suggest how conformational changes in specialized domains of the enzyme contribute to the catalytic cycle.
	20. 261 Accesses	Minireview Evolution underground: shedding light on the diversification of subterranean insects Carlos Juan, Brent C Emerson Journal of Biology 2010, 9:17 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Juan and Emerson discuss the reconstruction of the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade recently presented in BMC Evolutionary Biology, and the implications for the evolutionary origin of the beetle ancestor.
	21. 260 Accesses	Minireview Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'? Maria Grazia Lampugnani Journal of Biology 2010, 9:16 (8 April 2010) Abstract \| Full text \| PDF \| PubMed
	22. 254 Accesses	Minireview Genome of a songbird unveiled Raphael Pinaud Journal of Biology 2010, 9:19 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinaud heralds the publication of the zebra finch genome, reviewing some of the most exciting findings of this pioneering effort and explaining how this songbird model offers unique insights into auditory learning, singing behaviour and other biological phenomena.
	23. 251 Accesses	Minireview Making progress in genetic kin recognition among vertebrates Jane L Hurst, Robert J Beynon Journal of Biology 2010, 9:13 (17 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Highlighting recent research in BMC Evolutionary Biology that analyzes the scent profiles of ring-tailed lemurs in relation to their genetic distance, Hurst and Benyon discuss recent progress and remaining challenges in deciphering how vertebrates recognise kin by their smell.
	24. 233 Accesses	Minireview The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.
	25. 231 Accesses	Research article The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.
	26. 226 Accesses	Research article High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry Claude Lechene, Francois Hillion, Greg McMahon, Douglas Benson, Alan M Kleinfeld, J Patrick Kampf, Daniel Distel, Yvette Luyten, Joseph Bonventre, Dirk Hentschel, Kwon Park, Susumu Ito, Martin Schwartz, Gilles Benichou, Georges Slodzian Journal of Biology 2006, 5:20 (5 October 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary For the first time it is possible to image and quantify at nanometer resolution biological samples labeled with stable isotopes, using multi-isotope imaging mass spectrometry, applicable to all fields of biomedical research.
	27. 226 Accesses	Minireview Scale-eating cichlids: from hand(ed) to mouth A Richard Palmer Journal of Biology 2010, 9:11 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Palmer discusses recent studies, including one in BMC Biology, suggesting that mouth bending in scale-eating cichlids cannot be explained by frequency dependent selection alone, but that the behavior of the fish may amplify mouth asymmetry during growth.
	28. 225 Accesses	Minireview No better time to FRET: shedding light on host pathogen interactions Richard D Hayward, Jon D Goguen, John M Leong Journal of Biology 2010, 9:12 (18 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hayward and colleagues discuss the promise of fluorescence resonance energy transfer (FRET)-based techniques to study the spatio-temporal subversion of host cell signaling by pathogens, reviewing the few existing examples of this, which include a recent paper in BMC Biology, to illustrate the power of an approach that has been surprisingly under-exploited to date.
	29. 210 Accesses	Minireview Robust and specific inhibition of microRNAs in Caenorhabditis elegans Samrat T Kundu, Frank J Slack Journal of Biology 2010, 9:20 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Slack and Samrat Kundu highlight a refinement of the antisense strategy used to inhibit miRNAs in C.elegans, published in Silence, with an adaptation that supports transmission through the germline, and combinatorial use to target several different miRNAs in developing tissues.
	30. 207 Accesses	Minireview Parasite immunomodulation and polymorphisms of the immune system Rick M Maizels Journal of Biology 2009, 8:62 (5 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rick Maizels discusses a recent paper in BMC Biology on wild mammals that lend support to the hygiene hypothesis, and explains why genetic variants that reduce parasite-induced immunosuppression are associated with an increase in allergic reactions.
	31. 206 Accesses	Research article Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists Maria Frank-Kamenetsky, Xiaoyan M Zhang, Steve Bottega, Oivin Guicherit, Hynek Wichterle, Henryk Dudek, David Bumcrot, Frank Y Wang, Simon Jones, Janine Shulok, Lee L Rubin, Jeffery A Porter Journal of Biology 2002, 1:10 (6 November 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Characterization of small-molecule agonists and antagonists of the Hedgehog signaling pathway reveals that these candidate therapeutics act at the level of the pathway activator Smoothened, which may normally be regulated by an endogenous small molecule.
	32. 204 Accesses	Research article A circuit supporting concentration-invariant odor perception in Drosophila Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall Journal of Biology 2009, 8:9 (26 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila, inhibitory interneurons are progressively recruited as olfactory sensory neurons are activated at increasing odor concentrations, allowing the flies to identify distinct odors at different intensities.
	33. 204 Accesses	Minireview Timing the first human migration into eastern Asia Roscoe Stanyon, Marco Sazzini, Donata Luiselli Journal of Biology 2009, 8:18 (6 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments
	34. 194 Accesses	Question & Answer Q&A: Epistasis Frederick P Roth, Howard D Lipshitz, Brenda J Andrews Journal of Biology 2009, 8:35 (22 May 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The term epistasis has at least three meanings in biology. Brenda Andrews and colleagues explain in Q&A format how in its classical sense, epistasis allows biological pathways to be defined.
	35. 194 Accesses	Minireview Targeting TNF-α for cancer therapy Elizabeth R Burton, Steven K Libutti Journal of Biology 2009, 8:85 (23 October 2009) Abstract \| Full text \| PDF \| PubMed
	36. 190 Accesses	Editorial What are journals for? Miranda Robertson Journal of Biology 2009, 8:1 (27 January 2009) Full text \| PDF \| Editor’s summary Journal of Biology launches a re-review opt-out experiment in response to widespread dissatisfaction with peer review, and publishes the first of two new regular features - a full review on the ribosome and a question-and-answer feature on systems biology.
	37. 187 Accesses	Research article Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression Ian Conlon, Martin Raff Journal of Biology 2003, 2:7 (24 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| F1000 Biology
	38. 190 Accesses	Research article Global analysis of X-chromosome dosage compensation Vaijayanti Gupta, Michael Parisi, David Sturgill, Rachel Nuttall, Michael Doctolero, Olga K Dudko, James D Malley, P Scott Eastman, Brian Oliver Journal of Biology 2006, 5:3 (16 February 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila germ cells, X chromosome genes are upregulated to balance their expression with that of autosomes; the same happens in somatic cells of mice and nematodes.
	39. 187 Accesses	Research article Search for a 'Tree of Life' in the thicket of the phylogenetic forest Pere Puigbò, Yuri I Wolf, Eugene V Koonin Journal of Biology 2009, 8:59 (13 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Koonin and colleagues, comparing a forest of 7000 phylogenetic trees, discern vertical inheritance even at the earliest stages of prokaryotic evolution, despite horizontal gene transfer, but the branching order of the earliest radiations may never be resolved.
	40. 188 Accesses	Research article Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells Lars M Ittner, Heiko Wurdak, Kerstin Schwerdtfeger, Thomas Kunz, Fabian Ille, Per Leveen, Tord A Hjalt, Ueli Suter, Stefan Karlsson, Farhad Hafezi, Walter Born, Lukas Sommer Journal of Biology 2005, 4:11 (14 December 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Important structures in developing mouse eyes originate from neural crest cells controlled by TGFbeta signals from the lens, providing insight into human conditions that results in glaucoma and blindness.
	41. 186 Accesses	Research article The functional landscape of mouse gene expression Wen Zhang, Quaid D Morris, Richard Chang, Ofer Shai, Malina A Bakowski, Nicholas Mitsakakis, Naveed Mohammad, Mark D Robinson, Ralph Zirngibl, Eszter Somogyi, Nancy Laurin, Eftekhar Eftekharpour, Eric Sat, Jörg Grigull, Qun Pan, Wen-Tao Peng, Nevan Krogan, Jack Greenblatt, Michael Fehlings, Derek van der Kooy, Jane Aubin, Benoit G Bruneau, Janet Rossant, Benjamin J Blencowe, Brendan J Frey, Timothy R Hughes Journal of Biology 2004, 3:21 (6 December 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Gene function in mammals can be quickly and reliably predicted using a quantitative analysis of tissue-specific patterns of RNA expression.
	42. 183 Accesses	Research article The hydrodynamics of dolphin drafting Daniel Weihs Journal of Biology 2004, 3:8 (4 May 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Models of the hydrodynamic forces between two swimming dolphins show that baby dolphins keep up with their more powerful mothers by getting an almost energetically "free ride" in their slipstream.
	43. 183 Accesses	Opinion Why didn't Darwin discover Mendel's laws? Jonathan C Howard Journal of Biology 2009, 8:15 (24 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In an opinion piece, Jonathan Howard suggests that Darwin failed to discover the laws of inheritance (Mendel’s laws) due to his focus on small quantitative variations as the raw material of evolution.
	44. 183 Accesses	Minireview Regeneration review reprise Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.
	45. 181 Accesses	Minireview Making the jump: new insights into the mechanism of trans-translation Jacek Wower, Iwona K Wower, Christian Zwieb Journal of Biology 2008, 7:17 (30 June 2008) Abstract \| Full text \| PDF \| PubMed
	46. 180 Accesses	Research article Astrocytes derived from glial-restricted precursors promote spinal cord repair Jeannette E Davies, Carol Huang, Christoph Proschel, Mark Noble, Margot Mayer-Proschel, Stephen JA Davies Journal of Biology 2006, 5:7 (27 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Significantly better spinal cord repair in rats results from transplanting specific pre-differentiated cells, cultured to become immature neural-support cells, than from transplanting undifferentiated embryonic stem cells.
	47. 177 Accesses	Research article Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone, Frederick P Roth Journal of Biology 2005, 4:6 (1 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The multiple complex biological interactions in a yeast cell can be mapped in a simple graphical form, enhancing our understanding of the networks of interaction by which components of a cell influence one another.
	48. 176 Accesses	Research article A functional genomic analysis of cell morphology using RNA interference AA Kiger, B Baum, S Jones, MR Jones, A Coulson, C Echeverri, N Perrimon Journal of Biology 2003, 2:27 (1 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	49. 174 Accesses	Minireview The water flea Daphnia - a 'new' model system for ecology and evolution? Angelika Stollewerk Journal of Biology 2010, 9:21 (13 January 2010) Abstract \| Full text \| PDF \| PubMed
	50. 176 Accesses	Research article ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially Chiara Vantaggiato, Ivan Formentini, Attilio Bondanza, Chiara Bonini, Luigi Naldini, Riccardo Brambilla Journal of Biology 2006, 5:14 (28 June 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The mitogen-activated protein kinases ERK1 and ERK2 have unexpectedly independent roles in normal and malignant Ras-dependent cell proliferation; ERK2 controls normal cell proliferation whereas ERK1 antagonizes ERK2 activity.
	51. 175 Accesses	Minireview Metabolic reconfiguration is a regulated response to oxidative stress Chris M Grant Journal of Biology 2008, 7:1 (25 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	52. 174 Accesses	Minireview The effects of lipids on channel function Anthony G Lee Journal of Biology 2009, 8:86 (6 October 2009) Abstract \| Full text \| PDF \| PubMed
	53. 171 Accesses	Research article Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.
	54. 169 Accesses	Review Apes, lice and prehistory Robin A Weiss Journal of Biology 2009, 8:20 (10 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary In a special issue to celebrate the bicentennial of Darwin's birth, Robin Weiss reviews recent speculations on human prehistory based on louse phylogeny, and adds his own on the origins of pubic hair.
	55. 169 Accesses	Research article Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm Tadashi Okubo, Brigid LM Hogan Journal of Biology 2004, 3:11 (8 June 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Abnormal activation of the Wnt signaling pathway can alter the fate of progenitor cells that normally generate the lung, causing them to create gut cells instead.
	56. 167 Accesses	Review Notch signaling, the segmentation clock, and the patterning of vertebrate somites Julian Lewis, Anja Hanisch, Maxine Holder Journal of Biology 2009, 8:44 (22 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Julian Lewis and colleagues review the part played by the Notch signaling pathway in the emergence of somites from the embryonic mesoderm and their later differentiation.
	57. 167 Accesses	Research article Generalized immune activation as a direct result of activated CD4⁺T cell killing Rute Marques, Adam Williams, Urszula Eksmond, Andy Wullaert, Nigel Killeen, Manolis Pasparakis, Dimitris Kioussis, George Kassiotis Journal of Biology 2009, 8:93 (27 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary HIV causes immunodeficiency by deleting activated CD4 T lymphocytes, but paradoxically also causes general immune activation. Kassiotis and colleagues have mimicked this effect by using genetic engineering to delete activated T cells in mice, and show that in the mice it is due to loss of regulatory T cells.
	58. 168 Accesses	Research article Dosage compensation is less effective in birds than in mammals Yuichiro Itoh, Esther Melamed, Xia Yang, Kathy Kampf, Susanna Wang, Nadir Yehya, Atila Van Nas, Kirstin Replogle, Mark R Band, David F Clayton, Eric E Schadt, Aldons J Lusis, Arthur P Arnold Journal of Biology 2007, 6:2 (22 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Male:female ratios of gene expression in zebra finch and chicken reveal that birds, unlike mammals, have surprisingly ineffective sex-chromosome dosage compensation mechanisms resulting in an imbalance between autosomal and sex-linked genes.
	59. 166 Accesses	Opinion Promoter architecture and the evolvability of gene expression Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.
	60. 163 Accesses	Minireview Oxidative stress, thermogenesis and evolution of uncoupling proteins Eduardo Rial, Rafael Zardoya Journal of Biology 2009, 8:58 (16 June 2009) Abstract \| Full text \| PDF \| PubMed
	61. 163 Accesses	Minireview Adaptations of proteins to cellular and subcellular pH Bertrand Garcia-Moreno Journal of Biology 2009, 8:98 (2 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Protein function and stability are acutely sensitive to pH, which varies in different subcellular compartments. Garcia-Moreno discusses research recently reported in BMC Biology suggesting that adaptation to different compartments is reflected in charge distribution.
	62. 161 Accesses	Research article Environmental stresses can alleviate the average deleterious effect of mutations Roy Kishony, Stanislas Leibler Journal of Biology 2003, 2:14 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology
	63. 161 Accesses	Minireview Mapping the protistan 'rare biosphere' Scott C Dawson, Kari D Hagen Journal of Biology 2009, 8:105 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dawson and Hagen discuss our current underestimation of the ecological complexity of protist communities in the light of a recent paper in BMC Biology that reports an expanded map of microbial diversity using high throughput sequencing strategy.
	64. 160 Accesses	Research article Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury Jeannette E Davies, Christoph Pröschel, Ningzhe Zhang, Mark Noble, Margot Mayer-Pröschel, Stephen JA Davies Journal of Biology 2008, 7:24 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Glial cells can promote the repair of damaged spinal cord, but experiments in rats show that while some promote functional recovery others cause abnormal growth and pain, depending on the growth factor used to cultivate them in culture.
	65. 159 Accesses	Research article Systematic identification of regulatory proteins critical for T-cell activation Peter Chu, Jorge Pardo, Haoran Zhao, Connie C Li, Erlina Pali, Mary M Shen, Kunbin Qu, Simon X Yu, Betty CB Huang, Peiwen Yu, Esteban S Masuda, Susan M Molineaux, Frank Kolbinger, Gregorio Aversa, Jan de Vries, Donald G Payan, X Charlene Liao Journal of Biology 2003, 2:21 (15 September 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	66. 158 Accesses	Minireview Apical polarity in three-dimensional culture systems: where to now? Jamie L Inman, Mina J Bissell Journal of Biology 2010, 9:2 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	67. 155 Accesses	Research article CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo Joerg Dietrich, Ruolan Han, Yin Yang, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2006, 5:22 (30 November 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Chemotherapeutic agents are more toxic to cells of the central nervous system than to cancer cells when administered to mice and cultured cells, providing an explanation for adverse neurological effects of systemic chemotherapy.
	68. 155 Accesses	Minireview Genomics technology for assessing soil pollution Nico M van Straalen, Dick Roelofs Journal of Biology 2008, 7:19 (14 July 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	69. 152 Accesses	Minireview Adaptation by introgression Michael L Arnold, Noland H Martin Journal of Biology 2009, 8:82 (13 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	70. 151 Accesses	Minireview Limb regeneration revisited Jessica L Whited, Clifford J Tabin Journal of Biology 2009, 8:5 (13 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	71. 149 Accesses	Opinion The 'stem cell' concept: is it holding us back? Arthur D Lander Journal of Biology 2009, 8:70 (21 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary Arthur Lander argues that the molecular definition of a stem cell is a mirage and 'stemness' is an emergent property of cells in their physiological context, so that the current concept is arguably an obstacle to research.
	72. 148 Accesses	Minireview The cattle genome reveals its secrets David W Burt Journal of Biology 2009, 8:36 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.
	73. 146 Accesses	Minireview Regulation of metabolism in Caenorhabditis elegans longevity Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.
	74. 145 Accesses	Minireview The THO complex as a key mRNP biogenesis factor in development and cell differentiation Sonia Jimeno, Andrés Aguilera Journal of Biology 2010, 9:6 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The THO complex is implicated in RNA export from the nucleus, but exactly how is not clear. Jimeno and Aguilera discuss a new report on the THOC5 subunit in BMC Biology that suggests a role in differentiation.
	75. 145 Accesses	Research article Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function Owain R Millington, Caterina Di Lorenzo, R Phillips, Paul Garside, James M Brewer Journal of Biology 2006, 5:5 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hemozoin pigment, released during malarial infection, is now known to cause dendritic cell failure and subsequent host immunosupression, explaining why people with malaria become prone to infection and respond poorly to vaccines.
	76. 143 Accesses	Minireview TBP2 is a general transcription factor specialized for female germ cells Ferenc Müller, Làszlò Tora Journal of Biology 2009, 8:97 (30 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mueller and Tora discuss a BMC Biology paper that shows that TBP2 is highly similar to TATA binding proteins but is an oocyte-specific factor and is indispensable for female germ cell development in vertebrates.
	77. 140 Accesses	Research article Combined optical trapping and single-molecule fluorescence Matthew J Lang, Polly M Fordyce, Steven M Block Journal of Biology 2003, 2:6 (24 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	78. 138 Accesses	Editorial Ockham's broom: A new series Miranda Robertson Journal of Biology 2009, 8:79 (16 October 2009) Full text \| PDF \| PubMed
	79. 139 Accesses	Research article The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal Jens Böse, Achim D Gruber, Laura Helming, Stefanie Schiebe, Ivonne Wegener, Martin Hafner, Marianne Beales, Frank Köntgen, Andreas Lengeling Journal of Biology 2004, 3:15 (23 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The phosphatidylserine receptor is not needed for the recognition of dying cells as previously thought, and instead plays a role in the differentiation of a wide range of tissues during embryogenesis.
	80. 139 Accesses	Minireview RNA interference in nematodes and the chance that favored Sydney Brenner Marie-Anne Félix Journal of Biology 2008, 7:34 (13 November 2008) Abstract \| Full text \| PDF \| PubMed
	81. 136 Accesses	Research article Electrical protein detection in cell lysates using high-density peptide-aptamer microarrays David Evans, Steven Johnson, Sophie Laurenson, A Giles Davies, Paul Ko Ferrigno, Christoph Wälti Journal of Biology 2008, 7:3 (31 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Specific detection of protein isoforms in whole cell lysates is now more efficient with the arrival of a label-free electronic sensing system consisting of immobilized peptide aptamers on individual gold electrodes at the micron scale.
	82. 136 Accesses	Opinion The nature of cell-cycle checkpoints: facts and fallacies Alexey Khodjakov, Conly L Rieder Journal of Biology 2009, 8:88 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The development of the checkpoint concept was a landmark in the understanding of cell cycle control, but Alexey Khodjakov and Conly Rieder argue that it is widely misunderstood, to the detriment of progress in cell cycle research.
	83. 133 Accesses	Minireview Environmental stress and the effects of mutation Santiago F Elena, J Arjan GM de Visser Journal of Biology 2003, 2:12 (26 June 2003) Abstract \| Full text \| PDF \| PubMed
	84. 134 Accesses	Minireview Dishevelled and Wnt signaling: is the nucleus the final frontier? Raymond Habas, Igor B Dawid Journal of Biology 2005, 4:2 (17 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	85. 132 Accesses	Research article Evidence for large domains of similarly expressed genes in the Drosophila genome Paul T Spellman, Gerald M Rubin Journal of Biology 2002, 1:5 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	86. 132 Accesses	Minireview How chemotherapy damages the central nervous system Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	87. 128 Accesses	Question & Answer Q&A: What are pharmacological chaperones and why are they interesting? Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009) Full text \| PDF \| PubMed \| Editor’s summary Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
	88. 127 Accesses	Research article Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling Keiji Itoh, Barbara K Brott, Gyu-Un Bae, Marianne J Ratcliffe, Sergei Y Sokol Journal of Biology 2005, 4:3 (15 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, doesn't only function in the cytoplasm and at the cell membrane, but must be imported into the nucleus to perform at least one key aspect of its function.
	89. 125 Accesses	Research article Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production Margaret Q Wang, Wankee Kim, Guangxia Gao, Ted A Torrey, Herbert C Morse, Pietro De Camilli, Stephen P Goff Journal of Biology 2003, 3:4 (4 December 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	90. 125 Accesses	Minireview The gene complement of the ancestral bilaterian - was Urbilateria a monster? David J Miller, Eldon E Ball Journal of Biology 2009, 8:89 (19 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bilateral animals have selectively shed genes as they evolved from their hypothetical ancestor, Urbilateria. Miller and Ball review this genomic history and ask if a recent paper in BMC Evolutionary Biology points to an ancestral worm.
	91. 125 Accesses	Minireview Reprogramming of the non-coding transcriptome during brain development Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.
	92. 124 Accesses	Minireview Colugos: obscure mammals glide into the evolutionary limelight Robert D Martin Journal of Biology 2008, 7:13 (1 May 2008) Abstract \| Full text \| PDF \| PubMed
	93. 124 Accesses	Minireview Vernalization in cereals Elizabeth S Dennis, W James Peacock Journal of Biology 2009, 8:57 (22 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Elizabeth Dennis and James Peacock review recent advances in the molecular basis of the vernalization response that, with the increase in day length at the end of the winter season, triggers flowering.
	94. 124 Accesses	Minireview Cryptic biodiversity in a changing world Luciano B Beheregaray, Adalgisa Caccone Journal of Biology 2007, 6:9 (21 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	95. 121 Accesses	Research article A quantitative analysis of the mechanism that controls body size in Manduca sexta HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.
	96. 119 Accesses	Minireview Aquaglyceroporins: ancient channels for metalloids Hiranmoy Bhattacharjee, Rita Mukhopadhyay, Saravanamuthu Thiyagarajan, Barry P Rosen Journal of Biology 2008, 7:33 (7 November 2008) Abstract \| Full text \| PDF \| PubMed
	97. 119 Accesses	Minireview Genome degeneration affects both extracellular and intracellular bacterial endosymbionts Heike Feldhaar, Roy Gross Journal of Biology 2009, 8:31 (6 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Feldhaar and Gross discuss a new study in BMC Biology that suggests extracellular endosymbionts, like obligate intracellular bacteria, lose essential genes and become slaves to their hosts.
	98. 119 Accesses	Minireview Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology Andrew D Peel Journal of Biology 2009, 8:106 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peel discusses the merits of the flour beetle over the fruit fly as a new arthropod model organism and describes how a new mutagenesis screen published in BMC Biology increases the usefulness of this creature.
	99. 118 Accesses	Research article Adaptive evolution of centromere proteins in plants and animals Paul B Talbert, Terri D Bryson, Steven Henikoff Journal of Biology 2004, 3:18 (31 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Centromere-binding proteins, like the DNA they bind, are rapidly evolving, a remarkable finding given that they are essential for every cell division and so would be expected to be very highly conserved.
	100. 116 Accesses	Minireview At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation John M Kyriakis Journal of Biology 2003, 2:26 (22 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central