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	26. 264 Accesses	Research article Conservation of core gene expression in vertebrate tissues Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.
	27. 260 Accesses	Minireview The mathematics of sexual attraction José A Feijó Journal of Biology 2010, 9:18 (29 March 2010) Abstract \| Full text \| PDF \| PubMed
	28. 257 Accesses	Minireview Evolution underground: shedding light on the diversification of subterranean insects Carlos Juan, Brent C Emerson Journal of Biology 2010, 9:17 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Juan and Emerson discuss the reconstruction of the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade recently presented in BMC Evolutionary Biology, and the implications for the evolutionary origin of the beetle ancestor.
	29. 257 Accesses	Research article Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm Tadashi Okubo, Brigid LM Hogan Journal of Biology 2004, 3:11 (8 June 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Abnormal activation of the Wnt signaling pathway can alter the fate of progenitor cells that normally generate the lung, causing them to create gut cells instead.
	30. 250 Accesses	Opinion Why didn't Darwin discover Mendel's laws? Jonathan C Howard Journal of Biology 2009, 8:15 (24 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In an opinion piece, Jonathan Howard suggests that Darwin failed to discover the laws of inheritance (Mendel’s laws) due to his focus on small quantitative variations as the raw material of evolution.
	31. 248 Accesses	Research article CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo Joerg Dietrich, Ruolan Han, Yin Yang, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2006, 5:22 (30 November 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Chemotherapeutic agents are more toxic to cells of the central nervous system than to cancer cells when administered to mice and cultured cells, providing an explanation for adverse neurological effects of systemic chemotherapy.
	32. 247 Accesses	Research article The hydrodynamics of dolphin drafting Daniel Weihs Journal of Biology 2004, 3:8 (4 May 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Models of the hydrodynamic forces between two swimming dolphins show that baby dolphins keep up with their more powerful mothers by getting an almost energetically "free ride" in their slipstream.
	33. 244 Accesses	Minireview Scale-eating cichlids: from hand(ed) to mouth A Richard Palmer Journal of Biology 2010, 9:11 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Palmer discusses recent studies, including one in BMC Biology, suggesting that mouth bending in scale-eating cichlids cannot be explained by frequency dependent selection alone, but that the behavior of the fish may amplify mouth asymmetry during growth.
	34. 242 Accesses	Question & Answer Q&A: Epistasis Frederick P Roth, Howard D Lipshitz, Brenda J Andrews Journal of Biology 2009, 8:35 (22 May 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The term epistasis has at least three meanings in biology. Brenda Andrews and colleagues explain in Q&A format how in its classical sense, epistasis allows biological pathways to be defined.
	35. 240 Accesses	Minireview Genome of a songbird unveiled Raphael Pinaud Journal of Biology 2010, 9:19 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinaud heralds the publication of the zebra finch genome, reviewing some of the most exciting findings of this pioneering effort and explaining how this songbird model offers unique insights into auditory learning, singing behaviour and other biological phenomena.
	36. 238 Accesses	Minireview Timing the first human migration into eastern Asia Roscoe Stanyon, Marco Sazzini, Donata Luiselli Journal of Biology 2009, 8:18 (6 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments
	37. 237 Accesses	Review Apes, lice and prehistory Robin A Weiss Journal of Biology 2009, 8:20 (10 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary In a special issue to celebrate the bicentennial of Darwin's birth, Robin Weiss reviews recent speculations on human prehistory based on louse phylogeny, and adds his own on the origins of pubic hair.
	38. 236 Accesses	Research article The functional landscape of mouse gene expression Wen Zhang, Quaid D Morris, Richard Chang, Ofer Shai, Malina A Bakowski, Nicholas Mitsakakis, Naveed Mohammad, Mark D Robinson, Ralph Zirngibl, Eszter Somogyi, Nancy Laurin, Eftekhar Eftekharpour, Eric Sat, Jörg Grigull, Qun Pan, Wen-Tao Peng, Nevan Krogan, Jack Greenblatt, Michael Fehlings, Derek van der Kooy, Jane Aubin, Benoit G Bruneau, Janet Rossant, Benjamin J Blencowe, Brendan J Frey, Timothy R Hughes Journal of Biology 2004, 3:21 (6 December 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Gene function in mammals can be quickly and reliably predicted using a quantitative analysis of tissue-specific patterns of RNA expression.
	39. 233 Accesses	Research article Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression Ian Conlon, Martin Raff Journal of Biology 2003, 2:7 (24 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| F1000 Biology
	40. 233 Accesses	Research article Search for a 'Tree of Life' in the thicket of the phylogenetic forest Pere Puigbò, Yuri I Wolf, Eugene V Koonin Journal of Biology 2009, 8:59 (13 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Koonin and colleagues, comparing a forest of 7000 phylogenetic trees, discern vertical inheritance even at the earliest stages of prokaryotic evolution, despite horizontal gene transfer, but the branching order of the earliest radiations may never be resolved.
	41. 232 Accesses	Research article Astrocytes derived from glial-restricted precursors promote spinal cord repair Jeannette E Davies, Carol Huang, Christoph Proschel, Mark Noble, Margot Mayer-Proschel, Stephen JA Davies Journal of Biology 2006, 5:7 (27 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Significantly better spinal cord repair in rats results from transplanting specific pre-differentiated cells, cultured to become immature neural-support cells, than from transplanting undifferentiated embryonic stem cells.
	42. 227 Accesses	Research article A functional genomic analysis of cell morphology using RNA interference AA Kiger, B Baum, S Jones, MR Jones, A Coulson, C Echeverri, N Perrimon Journal of Biology 2003, 2:27 (1 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	43. 225 Accesses	Research article A circuit supporting concentration-invariant odor perception in Drosophila Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall Journal of Biology 2009, 8:9 (26 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila, inhibitory interneurons are progressively recruited as olfactory sensory neurons are activated at increasing odor concentrations, allowing the flies to identify distinct odors at different intensities.
	44. 221 Accesses	Minireview Targeting TNF-α for cancer therapy Elizabeth R Burton, Steven K Libutti Journal of Biology 2009, 8:85 (23 October 2009) Abstract \| Full text \| PDF \| PubMed
	45. 218 Accesses	Minireview No better time to FRET: shedding light on host pathogen interactions Richard D Hayward, Jon D Goguen, John M Leong Journal of Biology 2010, 9:12 (18 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hayward and colleagues discuss the promise of fluorescence resonance energy transfer (FRET)-based techniques to study the spatio-temporal subversion of host cell signaling by pathogens, reviewing the few existing examples of this, which include a recent paper in BMC Biology, to illustrate the power of an approach that has been surprisingly under-exploited to date.
	46. 219 Accesses	Research article Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells Lars M Ittner, Heiko Wurdak, Kerstin Schwerdtfeger, Thomas Kunz, Fabian Ille, Per Leveen, Tord A Hjalt, Ueli Suter, Stefan Karlsson, Farhad Hafezi, Walter Born, Lukas Sommer Journal of Biology 2005, 4:11 (14 December 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Important structures in developing mouse eyes originate from neural crest cells controlled by TGFbeta signals from the lens, providing insight into human conditions that results in glaucoma and blindness.
	47. 217 Accesses	Minireview Robust and specific inhibition of microRNAs in Caenorhabditis elegans Samrat T Kundu, Frank J Slack Journal of Biology 2010, 9:20 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Slack and Samrat Kundu highlight a refinement of the antisense strategy used to inhibit miRNAs in C.elegans, published in Silence, with an adaptation that supports transmission through the germline, and combinatorial use to target several different miRNAs in developing tissues.
	48. 215 Accesses	Minireview Oxidative stress, thermogenesis and evolution of uncoupling proteins Eduardo Rial, Rafael Zardoya Journal of Biology 2009, 8:58 (16 June 2009) Abstract \| Full text \| PDF \| PubMed
	49. 215 Accesses	Question & Answer Q&A: What are pharmacological chaperones and why are they interesting? Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009) Full text \| PDF \| PubMed \| Editor’s summary Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
	50. 213 Accesses	Research article A quantitative analysis of the mechanism that controls body size in Manduca sexta HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.