Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?
Vodovar N, Schweisguth F.
Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.
The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.
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PMID: 18312702 [PubMed - indexed for MEDLINE]PMCID: PMC2263122