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1:

Roughing up Smoothened: chemical modulators of hedgehog signaling.

King RW.

J Biol. 2002 Nov 6;1(2):8. Review.

PMID: 12437769 [PubMed - indexed for MEDLINE]

2:

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

PMID: 12437772 [PubMed - indexed for MEDLINE]

3:

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Chen JK, Taipale J, Cooper MK, Beachy PA.

Genes Dev. 2002 Nov 1;16(21):2743-8.

PMID: 12414725 [PubMed - indexed for MEDLINE]

4:

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Sinha S, Chen JK.

Nat Chem Biol. 2006 Jan;2(1):29-30. Epub 2005 Nov 20.

PMID: 16408088 [PubMed - indexed for MEDLINE]

5:

Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.

Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P Jr, Carlsson P, Melnick M.

Dev Dyn. 2004 Apr;229(4):722-32.

PMID: 15042696 [PubMed - indexed for MEDLINE]

6:

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA.

Nature. 2000 Aug 31;406(6799):1005-9.

PMID: 10984056 [PubMed - indexed for MEDLINE]

7:

Erythroid differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling.

Detmer K, Walker AN, Jenkins TM, Steele TA, Dannawi H.

Blood Cells Mol Dis. 2000 Aug;26(4):360-72.

PMID: 11042037 [PubMed - indexed for MEDLINE]

8:

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells.

Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F.

J Biol Chem. 2007 Mar 23;282(12):8959-68. Epub 2007 Jan 2.

PMID: 17200122 [PubMed - indexed for MEDLINE]

9:

Cancer: a twist in a hedgehog's tale.

Scott MP.

Nature. 2003 Oct 23;425(6960):780-2. No abstract available.

PMID: 14574396 [PubMed - indexed for MEDLINE]

10:

Targeting the hedgehog signaling pathway with small molecules.

Kiselyov AS.

Anticancer Agents Med Chem. 2006 Sep;6(5):445-9. Review.

PMID: 17017853 [PubMed - indexed for MEDLINE]

11:

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.

van der Horst G, Farih-Sips H, Löwik CW, Karperien M.

Bone. 2003 Dec;33(6):899-910.

PMID: 14678849 [PubMed - indexed for MEDLINE]

12:

Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity.

Tabs S, Avci O.

Eur J Dermatol. 2004 Mar-Apr;14(2):96-102.

PMID: 15196999 [PubMed - indexed for MEDLINE]

13:

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG.

Mol Cell Biol. 2006 Oct;26(20):7550-60. Epub 2006 Aug 14.

PMID: 16908539 [PubMed - indexed for MEDLINE]

14:

Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.

Incardona JP, Gaffield W, Lange Y, Cooney A, Pentchev PG, Liu S, Watson JA, Kapur RP, Roelink H.

Dev Biol. 2000 Aug 15;224(2):440-52.

PMID: 10926779 [PubMed - indexed for MEDLINE]

15:

Inhibition of the anti-adipogenic Hedgehog signaling pathway by cyclopamine does not trigger adipocyte differentiation.

Cousin W, Dani C, Peraldi P.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):799-803. Epub 2006 Aug 28.

PMID: 16949046 [PubMed - indexed for MEDLINE]

16:

Recruitment of the Sonic hedgehog signalling cascade in electroconvulsive seizure-mediated regulation of adult rat hippocampal neurogenesis.

Banerjee SB, Rajendran R, Dias BG, Ladiwala U, Tole S, Vaidya VA.

Eur J Neurosci. 2005 Oct;22(7):1570-80.

PMID: 16197497 [PubMed - indexed for MEDLINE]

17:

Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis.

Athar M, Li C, Tang X, Chi S, Zhang X, Kim AL, Tyring SK, Kopelovich L, Hebert J, Epstein EH Jr, Bickers DR, Xie J.

Cancer Res. 2004 Oct 15;64(20):7545-52.

PMID: 15492281 [PubMed - indexed for MEDLINE]

18:

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ.

Science. 2004 Dec 24;306(5705):2257-60.

PMID: 15618519 [PubMed - indexed for MEDLINE]

19:

Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.

Masdeu C, Faure H, Coulombe J, Schoenfelder A, Mann A, Brabet I, Pin JP, Traiffort E, Ruat M.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):471-9. Epub 2006 Aug 22.

PMID: 16945339 [PubMed - indexed for MEDLINE]

20:

Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

Chen W, Burgess S, Hopkins N.

Development. 2001 Jun;128(12):2385-96.

PMID: 11493557 [PubMed - indexed for MEDLINE]

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